# APLE > APLE is a Korea-based B2B supplier and exporter of professional K-Aesthetics products, including Korean dermal fillers, skin boosters, MTS devices and derma cosmetics for licensed dermatology and aesthetic clinics. APLE supplies Korean dermal fillers, skin boosters, MTS devices, derma cosmetics and professional treatment products sourced from Korean manufacturers. Dermal fillers and medical devices are supplied only to licensed medical professionals and authorized distributors. Pricing is provided on request. Product documentation may include MFDS, CE, CPNP, MoCRA or other market-specific documentation where applicable. Certification and registration status varies by product and destination country. ## Company - Website: https://aple.io/ - About: https://aple.io/about.html - Product catalog: https://aple.io/products.html - Contact (sales / wholesale): business@aple.io - CEO: Rio JEONG - Business Registration No. 882-02-03698 · Mail-Order Sales Registration No. 2025-Suwon Gwonseon-1166 - Address: Unit 404, Bldg. 404, 10 Dangsu-ro 129beon-gil, Gwonseon-gu, Suwon-si, Gyeonggi-do, Republic of Korea ## Key brands - TOSCANA (Colemedbio (Korea)): PLLA, CaHA+ and HA body fillers; PRO+ and EXO PRO+ skin boosters - REGLORY (EVIE KOREA): Exosome, PN, NAD+, HA and collagen skin boosters - MEDISCO (EVIE KOREA): Skin boosters, Meso line, Peelieve peel, SkinGlow Mask - Stayve (EVIE KOREA): MTS booster and BB Glow ampoules, Seanergy Peel, organic pigments, vegan clinic care - CHERIPS (EVIE KOREA): MTS lip ampoule sets - MISSMITO (EVIE KOREA): Wireless MTS / semi-permanent device and needles - LESIMO (LESIMO (Korea)): Non-comedogenic derma cosmetics ## Dermal Fillers Overview: https://aple.io/fillers.html - [TOSCANA PLLA](https://aple.io/products/toscana-plla.html) (TOSCANA): Poly-L-Lactic Acid collagen stimulator. A CE-certified sterile, absorbable PLLA dermal filler verified by the Korean Ministry of Food and Drug Safety (MFDS). - [TOSCANA CaHA+](https://aple.io/products/toscana-caha.html) (TOSCANA): New generation CaHA + cross-linked HA filler. Combines calcium hydroxyapatite with cross-linked hyaluronic acid — immediate correction from HA with long-term collagen synthesis from CaHA. - [TOSCANA BODY 70cc](https://aple.io/products/toscana-body70.html) (TOSCANA): Body contouring without surgery. Pharmaceutical-grade cross-linked HA body filler with patented stabilization technology, minimal BDDE usage and low degree of modification (MoD). - [TOSCANA10 Body Filler](https://aple.io/products/toscana10-body.html) (TOSCANA): Cross-linked HA body filler with MCO™ technology. Dense monophasic body filler built on MCO™ (Minimized Cross-linking Optimization) technology — maximum cross-linking efficiency with minimal BDDE for a stable, even gel, smooth injection pressure and consistent visco-elasticity. ## Skin Boosters Overview: https://aple.io/skin-boosters.html - [TOSCANA PRO+](https://aple.io/products/toscana-pro.html) (TOSCANA): Skin booster · NAD+ + PDRN + HA. Powerful energy, true repair. - [TOSCANA EXO PRO+](https://aple.io/products/toscana-exo.html) (TOSCANA): Exosome + PDRN + Collagen & Peptides. Plant-derived exosomes (Cica, Camellia — approx. 21 billion particles/mL) combined with high-purity PDRN 30,000ppm from wild Alaskan salmon, atelocollagen and seven amino-acid peptides for regeneration and barrier repair. - [REGLORY EXO+](https://aple.io/products/reglory-exo.html) (REGLORY): Human adipose-derived stem cell exosome. Contains 95% human adipose-derived stem cell conditioned media cultured in a serum-free medium, plus niacinamide, adenosine, sodium hyaluronate, sodium PCA and betaine. - [REGLORY PN+](https://aple.io/products/reglory-pn.html) (REGLORY): Polynucleotide skin booster. Advanced skin booster powered by polynucleotide (PN), sodium hyaluronate, niacinamide and glutathione — stimulates collagen, boosts elasticity, delivers deep hydration and brightening. - [REGLORY EYES](https://aple.io/products/reglory-eyes.html) (REGLORY): PN booster for the delicate eye area. Polynucleotide-based solution targeting fine lines, dark circles and signs of fatigue around the eyes for a refreshed, well-rested look. - [REGLORY NAD+ NMN](https://aple.io/products/reglory-nad.html) (REGLORY): Next-generation NAD+ skin booster. Revitalises skin energy from within. - [REGLORY HL 40+](https://aple.io/products/reglory-hl40.html) (REGLORY): High-concentration non-crosslinked HA. Non-crosslinked HA booster developed with proprietary high-concentration technology to overcome the elasticity and viscosity limits of conventional monophasic and biphasic products. - [REGLORY RH Collagen](https://aple.io/products/reglory-rh.html) (REGLORY): Recombinant human collagen I & III. Recombinant human collagen types I and III with high-molecular HA, succinic acid and polynucleotide for regeneration, elasticity and anti-aging. - [MEDISCO Meso](https://aple.io/products/medisco-meso.html) (MEDISCO): PDRN · Glutathione · Vitamin C. Skin booster line in three formulas — Meso PDRN, Meso Glutathione and Meso Vitamin C — for MTS protocols. ## MTS & Medical Devices Overview: https://aple.io/mts-devices.html - [MISSMITO Wireless Machine](https://aple.io/products/missmito.html) (MISSMITO): Wireless MTS & semi-permanent device. Portable, wire-free pen for both microneedling therapy (MTS) and semi-permanent procedures. - [MEDISCO Skinbooster](https://aple.io/products/medisco-skinbooster.html) (MEDISCO): Premium MTS skin booster. Next-generation premium skin booster evolved from the Stayve Booster Ampoule, optimised for MTS with enhanced ingredients and a refined, high-stability formula. - [Stayve Booster Ampoule](https://aple.io/products/stayve-booster.html) (STAYVE): 9 MTS ampoules for every skin type. Premium ampoules designed for microneedling — absorbed up to three times more effectively as needles open micro-channels. - [Stayve BB Glow Ampoule](https://aple.io/products/bbglow.html) (STAYVE): Semi-permanent glow & coverage. Nourishes the skin for a bright, radiant finish with immediate coverage and long-lasting beauty, formulated for MTS. - [CHERIPS Lip Ampoule Set](https://aple.io/products/cherips.html) (CHERIPS): MTS lip tint treatment. Simple, quick and nearly painless tint treatment for natural, vital lips — no swelling, easy colour change, and daily life right after the procedure. - [Stayve Organic Pigment](https://aple.io/products/pigment.html) (STAYVE): 29 derma-safe organic colours. Organic pigments for permanent make-up with vivid colour and excellent tint strength — eyeliner, eyebrows, lips, correction, camouflage and booster solution. ## Peeling Overview: https://aple.io/peeling.html - [Seanergy Peel](https://aple.io/products/seanergy.html) (STAYVE): Spicule peel from deep-sea coral calcium. Sea + Energy. - [Peelieve Peeling](https://aple.io/products/peelieve.html) (MEDISCO): Gentle ampoule-texture spicule peel. Viscous, ampoule-like spicule peel with finer particles for a gentler experience. ## Derma Cosmetics Overview: https://aple.io/derma-cosmetics.html - [Willow Bark Line](https://aple.io/products/lesimo-willow.html) (LESIMO): Pore-concern skin solution. Clinically non-comedogenic line for acne-prone skin — pore serum, toner, gentle exfoliating cleanser, jojoba blackhead cleansing oil and skinglow mask to clear sebum, refine pores and smooth texture. - [Niacinamide & Hyaluronic Serums](https://aple.io/products/lesimo-serums.html) (LESIMO): Tone & hydration solutions. Niatamin B3 10% Serum for clear, even tone and Hyaluronic Acid Aqua Serum for instant, all-day moisture — both suitable for acne-prone skin. - [MEDISCO SkinGlow Mask](https://aple.io/products/skinglow-mask.html) (MEDISCO): 70+1 collagen wash-off mask. A special mask that wraps the skin in collagen and rich nutrients — ideal as a post-treatment finish to soothe and illuminate. - [EVE Vegan Clinic Care](https://aple.io/products/stayve-vegan.html) (STAYVE): Pre & post-treatment essentials. Clinic back-bar essentials: Mild Cleansing Milk, Hydrating Rose Toner and Repair Cream (vegan), plus Dermawhite Exfoliating Gel with mandelic acid and Neutralising Foam. ## Frequently asked questions ### What is APLE? APLE is a Korea-based B2B supplier and exporter of professional K-Aesthetics products, including Korean dermal fillers, skin boosters, MTS devices and derma cosmetics for licensed dermatology and aesthetic clinics. ### What is a PLLA filler? A PLLA (poly-L-lactic acid) filler is a biodegradable collagen stimulator. Instead of adding volume directly, its microparticles trigger the skin's own collagen production, restoring volume gradually over several sessions with results lasting about 18–24 months. Example: TOSCANA PLLA. ### How is a CaHA + HA hybrid filler different from an HA filler? An HA filler gives immediate volume but no collagen stimulation and typically lasts around a year. A CaHA + cross-linked HA hybrid combines immediate HA correction with long-term collagen synthesis from calcium hydroxyapatite, shows no migration and can still be dissolved with hyaluronidase. Example: TOSCANA CaHA+. ### What is PDRN in skin boosters? PDRN (polydeoxyribonucleotide) is a DNA-derived molecule, usually extracted from salmon, that supports tissue repair and regeneration by activating fibroblasts and collagen production. It is used for skin regeneration, post-acne recovery and anti-inflammatory care. Examples: TOSCANA PRO+, TOSCANA EXO PRO+. ### What is an exosome skin booster? An exosome skin booster delivers nano-sized vesicles that carry growth factors and signalling molecules to support regeneration, hydration and skin-tone improvement. They are either human adipose stem cell–derived or plant-derived (e.g. Centella Asiatica) and are applied with MTS. Example: REGLORY EXO+. ### What does NAD+ do in a skin booster? NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that powers cellular energy (ATP), DNA repair and sirtuin activity. Its levels decline with age, so NAD+ boosters aim to restore skin vitality and slow visible aging. Examples: REGLORY NAD+ NMN, TOSCANA PRO+. ### What is a spicule (coral calcium) peel? A spicule peel uses microscopic, mineral-rich spicules from coral calcium that embed in the skin for 36–48 hours, stimulating circulation and cell turnover without chemical acids. Intensity is adjusted from mild to strong by the amount of powder and rubbing time. Examples: Seanergy Peel, Peelieve Peeling. ### Who can purchase from APLE? Dermal fillers and medical devices are supplied only to licensed medical professionals, dermatology clinics and aesthetic businesses. Derma cosmetics are available to clinics, spas and authorised resellers. ### How do I get clinic pricing? Email business@aple.io with your clinic name, country and the products you are interested in. We will reply with a price list and minimum order details. ### Do you ship internationally? We handle both domestic (Korea) and export orders. Availability depends on each product's registration status in your country — contact us and we will confirm. ### Can I receive certificates and full catalogs? Yes. Full English catalogs and treatment protocols are available on request, together with the certification or registration documents that apply to each product (for example MFDS, CE, CPNP or MoCRA). Status varies by product and destination country. ### Do you provide treatment training? We share manufacturer protocols — dilution, application depth and post-treatment care — and can arrange product training for partner clinics.